Who will be Spiderman's foes in the next sequel to Spiderman? Well the question can't be answered so far as even the production probably doesn't know it: they're still working on a draft of the synopsis.
Let's try to guess who could be the mortal enemy:
(click on the picture to enlarge)
1. Lizzard (aka Dr. Curt Connors who appeared in Spiderman 3) Good chance to my viewpoint too !2. Electro
3. Hydroman
4. Mysterio Unlikely, but I like the idea of a Mysterio ;-)
5. Carnage Highly probable! Remember: Dr. Curt Connors still has a sample of Venom...
6. Chameleon
7. Shocker
8. Vulture
9. HogGoblin
10. Rhino
Well let's be honest: for now, quite difficult to really guess who will be the next super-villain in Spiderman 4...
But maybe the truth is out there. Should ask to Madame Web !
And what if she's in the cast of Spiderman 4 ? ;-p